Spatiotemporally-resolved Chemoproteomics

Publications

Wei Qin (0009-0007-4061-2326) – ORCID

At Tsinghua University

  1. Wang, YK.; Qin, W*. Revealing protein trafficking by proximity labeling-based proteomics. Bioorganic Chemistry. 2023. https://doi.org/10.1016/j.bioorg.2023.107041（Special issue: Emerging Investigators in Chemical Biology in China https://www.sciencedirect.com/journal/bioorganic-chemistry/special-issue/106VRV6G21W）

Prior to Tsinghua University

  1. Qin, W. #; Cheah, JS. #; Xu, C.; Messing, J.; Freibaum, BD.; Boeynaems, S.; Taylor, JP.; Udeshi, ND.; Carr, SA.; Ting, AY*. Dynamic mapping of proteome trafficking within and between living cells by TransitID. Cell . 2023.（#EqualContribution)　https://pubmed.ncbi.nlm.nih.gov/36798302/
  2. Qin, W.; Samuel, MA.; Carey, CK.; Carr, SA.; Ting, AY*., Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery. Nat. Commun. 2021. https://pubmed.ncbi.nlm.nih.gov/34404792/
  3. Qin, W. #; Cho, FK. #; Cavanagh, PE. #; Ting AY*., Deciphering Molecular Interactions by Proximity Labeling. Nat. Methods. 2021. (# EqualContribution) https://pubmed.ncbi.nlm.nih.gov/33432242/
  4. Liu, J. #; Shao, X. #; Qin, W.#; Zhang, Y. #; Dang, F.; Yang, Q.; Yu, X.; Li, YX.; Chen, X.*; Wang, C.*; Wang, YL.*, Quantitative Chemoproteomics Reveals O-GlcNAcylation of Cystathionine γ-lyase Represses Trophoblast Syncytialization. Cell Chem. Biol. 2021. (# EqualContribution) (Selected as cover) https://pubmed.ncbi.nlm.nih.gov/33626323/
  5. Qin, W.#; Zhang, Y.#; Tang, H.; Liu D.; Chen, Y.; Liu, Y.; Wang, C.*, Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages. J. Am. Chem. Soc. 2020. (# EqualContribution) https://pubmed.ncbi.nlm.nih.gov/32496768/
  6. Qin, W.; Qin, K.; Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou, W.; Wang, YL.; Chen, X.*; Wang, C.*, S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10), 983-991. https://pubmed.ncbi.nlm.nih.gov/31332308/
  7. Qin, W.#; Qin, K.#; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Wang, C.*; Chen, X.*, Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling. Angew. Chem. Int. Ed. 2018, 57 (7), 1817-1820. (# EqualContribution) (Selected as back cover and very important paper) https://pubmed.ncbi.nlm.nih.gov/29237092/
  8. Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.*; Chen, X.*, Quantitative Time-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis. Proc. Natl. Acad. Sci. USA 2017, 114 (33), E6749-e6758. https://pubmed.ncbi.nlm.nih.gov/28760965/
  9. Qin, W.; Xie, Z.; Wang, J.; Peng, L; Ou, G.; Wang, C.*; Chen, X.*, Chemoproteomic Profiling of Protein O-GlcNAcylation in Caenorhabditis Elegans. Biochemistry 2019, doi: 10.1021/acs.biochem.9b00622. https://pubmed.ncbi.nlm.nih.gov/31682414/
  10. Qin, W.; Yang, F.; Wang, C.*, Chemoproteomic Profiling of Protein-Metabolite Interactions. Curr. Opin. Chem. Biol. 2019, 54, 28-36. https://pubmed.ncbi.nlm.nih.gov/31812894/
  11. Zhang, Y.; Qin, W.; Liu D.; Liu, Y.; Wang, C.*, Chemoproteomic profiling of itaconations in Salmonella. Chem. Sci. 2021. https://pubmed.ncbi.nlm.nih.gov/33996001/
  12. Zhang, Y.; Qin, W.; Wang, C.*, Discovery of post-translational modifications in immunometabolism by chemical proteomics. Curr. Opin. Biotech. 2021, 68, 1-7. https://pubmed.ncbi.nlm.nih.gov/33113497/
  13. Hao, Y.#; Fan, X.#; Shi, Y.; Zhang, C.; Sun, DE.; Qin, K.; Qin, W.; Zhou, W.; Chen, X.*, Next-generation Unnatural Monosaccharides Reveal that ESRRB O-GlcNAcylation Regulates Pluripotency of Mouse Embryonic Stem Cells. Nat. Commun. 2019, 10 (1), 4065. (# EqualContribution) https://pubmed.ncbi.nlm.nih.gov/31492838/
  14. Qin, K.#; Zhu, Y.#; Qin, W.; Gao, J.; Shao, X.; Wang, Y.; Zhou, W.*; Wang, C.*;. Chen, X.*, Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker. ACS Chem. Biol. 2018, 13(8),1983-1989. (# EqualContribution) https://pubmed.ncbi.nlm.nih.gov/30059200/
  15. Chen, Y.; Liu, Y.; Lan, T.; Qin, W.; Zhu, Y.; Qin, K.; Gao, J.; Wang, H.; Hou, X.; Chen, N.; Friedmann Angeli JP.; Conrad M.; Wang, C.*, Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe. J. Am. Chem. Soc. 2018, 140, 4712-4720. https://pubmed.ncbi.nlm.nih.gov/29569437/
  16. Chen, Y.; Qin, W.; Wang, C.*, Chemoproteomic Profiling of Protein Modifications by Lipid-derived Electrophiles. Curr. Opin. Chem. Biol.2016, 30, 37-45. https://pubmed.ncbi.nlm.nih.gov/26625013/
  17. Liu, Y.; Liu, K.; Qin, W.; Liu, C.; Zheng, X.; Deng, Y.; Qing, H.*, Effects of Stem Cell Therapy on Protein Profile of Parkinsonian Rats Using an 18 O-labeling Quantitative Proteomic Approach. Proteomics2016, 16 (6), 1023-32. https://pubmed.ncbi.nlm.nih.gov/26791447/